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What is methotrexate? What is its machinery of accomplishment? - 666health.com/Diseases-Conditions

What is methotrexate? What is its machinery of accomplishment? - 666health.com/Diseases-Conditions

What is methotrexate? What is its machinery of accomplishment?

Source:666health.com/Diseases-Conditions Author:DiseasesDate:09-08 07:11:55 2008

Answers: Methotrexate is a folic acid analogue which inhibits dihydrofolate reductase and the formation of the 1-carbon delivery service needed in purine and thymine synthesis.

This reduce T and B cell activation, apoptosis of activated T cell and less Ab production.

Hope this help!Methotrexate (rINN) (pronounced /mθ''trkset/), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used contained by treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acerbic. Methotrexate replaced the more powerful and toxic antifolate aminopterin, and the two should not be confused with respectively other.

While mechanism of achievement refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of performance usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor.

For example, the workings of action of aspirin involved irreversible inhibition of the enzyme cyclooxygenase, which suppresses the production of prostaglandins and thromboxanes thereby reducing spasm and inflammation.Methotrexate belongs to the group of medicines specified as antimetabolites. It is used to treat cancer of the breast, head and nouns, lung, blood, bone, and lymph, and tumors in the uterus. It may also be used to treat other kind of cancer, as determined by your doctor.

Methotrexate blocks an enzyme needed by the cell to live. This interferes with the growth of cancer cell, which are eventually destroyed. Since the growth of normal body cell may also be affected by methotrexate, other effects will also go on. Some of these may be serious and must be reported to your doctor. Other effects, like mane loss, may not be serious but may cause concern. Some effects may not come to pass for months or years after the medicine is used.

Before you start treatment with methotrexate, you and your doctor should verbalize about the worthy this medicine will do as ably as the risks of using it.

Please see the web page for more details on Methotrexate.Methotrexate is used to treat certain types of cancer of the breast, skin, team leader and neck, or lung. It works by blocking an enzyme needed for cell growth, especially the cell that reproduce quickly, such as cancer cell, bone marrow cells, and skin cell. . This helps to slow the growth of cancer cell and abnormal skin cell.

Methotrexate can also be used to treat severe psoriasis and rheumatoid arthritis. Exactly how Methotrexate works to treat rheumatoid arthritis is unknown. It reduces symptoms of inflammation (e.g., affliction, swelling, stiffness) caused by rheumatoid arthritis.

Methotrexate may lead to severe and sometimes fatal side effects. These may include bone marrow, blood, liver, lung, kidney, or skin problems. For this defence, Methotrexate is only used to treat consistent patients who have life-threatening cancer or who enjoy severe psoriasis or rheumatoid arthritis that is not relieved by other treatments.The pills and health information post by website user , 666health.com not guarantee correctness , is for informational purposes just and is not a substitute for medical advice or treatment for any medical conditions.

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